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KMID : 0378020020450110023
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New Medical Journal
2002 Volume.45 No. 11 p.23 ~ p.34
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Effects of an Angiotensin Converting Enzyme Inhibitor and an Angiotensin Ⅱ Receptor Blocker on Restenosis Induced by Balloon Angioplasty in Rat Thoracic Aorta
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Abstract
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The aim of this study is to investigate effects of candesartan cilexetil and enalapril (p.o.10 mg/kg/day) on functional and histological changes of the restenosis aorta induced by the balloon angioplasty (AP) via left carotid artery in the rat thoracic aorta. Experimental groups were divided into the following groups. Control group: Rats with sham operation; AP groups (AP-0w, AP-1w, AP-3w); candesartan+AP treated groups (AP-CAn-0w, AP-CAn-1w, Ap-Can-3w); enalapril+AP treated group (AP-ENa-0w, AP-Ena-1w, AP-Ena-3w).
Microscopic analysis showed that endothelial cells in AP-0w group certainly were impaired and the smooth cells in AP-Can-3w group showed abnormal hypertrophic pattern. Contractile responses to norepinephrine (NE) and 5-hydroxytryptamine (5-HT) were significantly potentiated in both AP-0w and AP-Can-0w groups than those in the control, and relaxant responses to acetylcholine (ACh) were abolished in the both groups. However, the relaxations of sodium nitroprusside (SNP) were not affected by AP only. Contractions in NE and 5-HT did not differ in both AP-0w and AP-Can-1w groups, but the contractions were decreased in AP-Can-3w and AP-Ena-3w groups to compare with those in AP-3w group. Relaxations of ACh and SNP in AP-Can-1w group are more sensitive than those in AP-1w group.
Above results suggest that candesartan improves, in a part, the endothelial dysfunction induced by the balloon angioplasty and there are somewhat different between effects of an AT1-receptor blocker and ACE inhibitor on the restenosis process in thoracic aorta of rats.
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